is a health condition that results from very high cholesterol levels in the blood. The impact of increased cholesterol is the improved chances of heart diseases and stroke. Additionally, dense cholesterol in the blood creates sticky deposits on the arterial walls which can ultimately lead to the blockage of blood that flows to other body organs. is associated with certain pathophysiological factors that pose as risk factors for the incidence of acute, periodic, or chronic diseases in people of diverse age groups (Glozier, 2013).

Risk factors

  1. Nutrition in Transition

First, the changes in dietary structure encompass considerable increases in the intake of fats. It is marked by the reduced ingestion of animal products, as well as, a decline in consumption of organic cereals. The today’s diets, that contain high levels of fat, low carbohydrates, and extra salt, lead to the manifestation of chronic diseases. On the other hand, the traditional diets, which have low-fat levels and high crude carbohydrates, are known to protect populations against the incidence of chronic diseases (McCance &amp Huether, 2015).

  1. Obesity

Secondly, uncontrolled eating highly increases an individual’s risk for acquiring conditions such as hypertension, type-2 diabetes, and dyslipidemia. It is also related to coronary artery illness and several cancers. Equally, obesity is connected to metabolic syndromes. The main issues that result from uncontrolled eating include high blood pressure, elevated insulin levels, as well as poor insulin resistance. More importantly, the condition predisposes one to a prominent risk of cardiovascular disease and diabetes (McCance &amp Huether, 2015).

  1. Dyslipidemia

Third, dyslipidemia or the clinical changes on the naturally occurring lipids and lipoproteins in the blood, predisposes one to various chronic diseases including cardiovascular illnesses amongst other ailments. A mixture of oils and the other risk factors causes untimely coronary heart diseases (Glozier, 2013). The syndrome entails high levels of triglyceride and fewer HDL cholesterols. It is related to hypertension, type-2 diabetes, and abdominal obesity.

Lack of Physical inactivity

Inadequate physical activity has many health deteriorating features. It has a direct role in increasing cardiovascular diseases and early mortality. Traditionally, it is believed that high physical exercise levels could partially clarify the low incidents of chronic conditions as seen in Sub-Saharan Africa nations. The amount of physical activity has been declining because of the high rate of industrialization that is evident across the globe. Reduced physical exercise is one of the major contributors to chronic diseases in populations today (McCance &amp Huether, 2015)


Nutrition in transition, obesity, dyslipidemia and lack of physical exercise, have been acknowledged as some of the main and direct risk factors for hypercholesterolemia-related illnesses. The consequences of increased cholesterol levels can be severe. Most remarkably, high cholesterol intensifies the likelihood of heart infections. The high amounts of cholesterol in blood contribute to heart attack and atherosclerosis. Moreover, high cholesterol level is a causative factor of a metabolic set of symptoms that raises the chances of coronary heart diseases (McCance &amp Huether, 2015). The relation between type-2 diabetes and obesity is one amongst the severest disease–risk factor connections known today. Apparently, the rates of chronic diseases are now higher than normal. As a result, patients are causing serious burdens on the few available health practitioners and facilities (Kure, 2016). Hospitals intended for care and prevention are left with the burden of numerous chronic infection risk factors. This translates to complications and economic problems.


The conventional treatment of hypercholesterolemia is the intake of cholesterol-depressing drugs. Such medications include atorvastatin, rosuvastatin, and simvastatin. They are essential in inhibiting the liver enzymes which function in the production of cholesterol. Similarly, patients can use Niacin which is an element of B vitamin. It is used to decrease triglycerides and increase HDL cholesterol. Lastly, Ezetimibe may help lower the digestion of cholesterol within the gut.


Conclusively, hypercholesterolemia causes health complications and it is related to the accumulation of cholesterol in tissues. In a case of an accumulation of cholesterol in tendons, there can be severe health impacts on individuals, and the consequences may remain for the rest of their lives. The majority of the risk factors occur during middle age due to poor lifestyles that individuals adopt once they began experiencing fatigue and become unable to take care of themselves (Kure, 2016).


Glozier, N., (2013). Psychosocial Risk Factors for Coronary Heart Disease. Med J Aust, 199(3), 179-180.

Kure, C. E., (2016). Gender-Specific Secondary Prevention? Differential Psychosocial Risk Factors for Major Cardiovascular Events. Open heart, 3(1), e000356.

McCance, K. L., &amp Huether, S. E. (2015). Pathophysiology: The Biologic Basis for Disease in Adults and Children. Elsevier Health Sciences.